VU-0152100

VU-0152100 is a positive modulator of the M4 receptor, one of the muscarinic acetylcholine receptors.

Treatment of stimulant addiction

In mice, VU-0152100 is able to decrease self-administration of cocaine, this is thought to come from the M4 receptor's action on D1 containing dopaminergic neurons. It is also able to almost completely inhibit the hyperactivity caused by cocaine. Another study has shown that this drug is able to reverse hyperlocomotion induced by amphetamine, in an anti-psychotic-like manner. This data suggests that it could potentially be developed as a treatment for stimulant abuse.

See also

• VU-0152099

References